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Letrozole is also known as Femara trademarked by Novartis selective third-generation aromatase inhibitor (AI), a drug that works by blocking the aromatase enzyme responsible for the production of estrogen. The chemical definition of Letrozole is 4,4’ -(1H-1,2,4-Triazole-1ylmethylene) dibenzonitrile.
Letrozole is the aromatase inhibitor of choice. The drug is appropriately used when using substantial amounts of aromatizing steroids, or when one is prone to gynecomastia and using moderate amounts of such steroids.
Letrozole has been shown to reduce estrogen levels by as much as 98%. Letrozole has proven to reduce test subject’s estrogen to undetectable levels while increasing LH, FSH, and SHBG. For the bodybuilder – the less estrogen in the body means – less chance of estrogen-related side effects. For this reason alone, this makes Letrozole an appropriate choice for even the heaviest bulking or cutting cycles even including those cycles which incorporate advance androgens.
For the advanced requirements of Letrozole, it is a must-have product for competitive athletics that require low body fat as no other ancillary compound supports the coveted dry and tight appearance quite as well.
Effective dosage of Letrozole is .25 to .5mg/day. Moreover, this amount will reduce libido quite dramatically. To be noted also is Letrozole’s substantial estrogen rebound effect that occurs after discontinuation. Maximum inhibition of the aromatase enzyme has been cited at doses as low as 100 mcg.
The effects Letrozole has on serum lipids including cholesterol, both HDL and LDL are inconsistent. Remember and take into consideration that you can suffer an impaired lipid profile and immune system if the estrogen levels remain too low for long periods. As previously mentioned, Letrozole can be used to raise LH and FSH, these are hormones that signal your testes to produce more testosterone. These characteristics mean that Letrozole can be used for post-cycle therapy (PCT).
Additional Letrozole Characteristics:
Letrozole may also reduce/eliminate/reverse existing gynecomastia. Results also indicate aromatase overexpression-induced changes in mammary glands can be destroyed with very low concentrations of the aromatase inhibitor, Letrozole.
Dosage Recommendation: 1.25mg-2.5mg daily
Active Half Life: 2 days